|
KMID : 0364219810240030163
|
|
Korean Journal of Zoology
1981 Volume.24 No. 3 p.163 ~ p.171
|
|
|
Studies on Chromosome Aberrations Induced N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea in CHO cells
|
|
Kim Choon-Kwang
|
|
|
Abstract
|
|
|
|
Chromosome aberrations induced by ENU and MNU were investigated in CHO cells at various doses and times after treatment. The results obtained were as follows: The frequency of chromosome aberrations induced by ENU and MNU drastically depends on the length of the post-treatment period and the concentration of these chemicals. In ENU-treated groups, the major type of aberration was chromatid deletions in earlier samples but the frequency of chromatid exchanges increased with time, revealing, predominant type at 24 hours after treatment with $10^-3$ M. In MNU-treated groups, chromatid deletions were also major type but frequency of chromatid exchanges were predominant from 12 hours after treatment with $10^-4$ and $10^-5$ M.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|